An ampullary neoplasm is a type of tumor that develops in the ampulla of Vater and can be benign (noncancerous) or malignant (cancerous). If the neoplasm is benign, it may be completely removed during the endoscopic procedure. If the neoplasm is malignant, it may be partially removed to help relieve symptoms and improve quality of life.


The procedure is typically performed in a hospital under general anesthesia and takes about an hour to complete. It may be done as an open surgery or laparoscopically, depending on the specifics of the case. Endoscopic ampullectomy is a procedure in which a small, narrow tube with a light and camera on the end (called an endoscope) is used to remove a portion of the small intestine called the ampulla of Vater.


This procedure is typically done to remove a growth or abnormal tissue, such as a polyp, from the ampulla. It may also be done to treat certain conditions, such as pancreatitis or bile duct obstruction. 

Risks & Benefits of Endoscopic Ampullectomy

As with any medical procedure, there are risks and benefits associated with endoscopic ampullectomy. It is important to discuss these with your doctor to determine if the procedure is appropriate for you.



  • A minimally invasive procedure, which means it involves smaller incisions and may result in a shorter recovery time compared to open surgery.
  • Allows the doctor to directly visualize and remove the growth or abnormal tissue.
  • May be used to treat a variety of conditions, including pancreatitis, bile duct obstruction, and ampullary neoplasms.


  • Bleeding and infection after the procedure.
  • Perforation (tearing) of the intestine during the procedure.
  • Adverse reactions to the anesthesia used during the procedure.
  • In rare cases, the procedure may not completely remove the growth or abnormal tissue, and additional surgery may be needed.


The risks of endoscopic ampullectomy include bleeding, infection, and perforation of the intestine. There is also a risk of adverse reactions to the anesthesia used during the procedure.

Recovery time after endoscopic ampullectomy may vary, but most people are able to return to their normal activities within a week. It is important to follow your doctor’s instructions for care after the procedure to help ensure a smooth recovery.

In many cases, endoscopic ampullectomy is performed on an outpatient basis, meaning you will be able to go home the same day as the procedure. However, if you have other medical conditions or if there are complications during the procedure, you may need to stay in the hospital for a longer period of time.

You may need to follow a special diet after endoscopic ampullectomy to allow your intestine to heal. Your doctor will provide specific instructions on what you can and cannot eat.

Endoscopic ampullectomy may be used to remove growths or abnormal tissue from the ampulla of Vater, including cancerous growths. However, it is typically not the primary treatment for cancer and may be used in conjunction with other treatments, such as chemotherapy or radiation.

Endoscopic ampullectomy is typically performed under general anesthesia, so you should not feel any pain during the procedure. You may experience some discomfort or pain after the procedure, which can be managed with pain medication prescribed by your doctor.

The length of the endoscopic ampullectomy procedure can vary, but it typically takes about an hour to complete.

Your doctor will likely schedule a follow-up appointment after your endoscopic ampullectomy to ensure that you are recovering well and to check for any complications.

Endoscopic ampullectomy can be performed either as an open surgery or laparoscopically, which means using small incisions and special instruments to access the ampulla of Vater. The decision on whether to perform the procedure laparoscopically or as an open surgery will depend on the specifics of your case and your doctor’s recommendation.

Endoscopic ampullectomy may be covered by insurance, but it is important to check with your insurance provider to confirm coverage.